Syria's state news agency reported six soldiers were wounded and several buildings destroyed after what it said was an Israeli air strike.
The strike took place in the province of Hama, northeast of the Lebanese border, the Sana agency said.
The Syrian Observatory for Human Rights, which is based in London, said the jets struck three targets and that some soldiers were killed, although it was not clear whether these were Iranian or Iran-sponsored fighters.
The IDF, which does not usually comment on reports of its activities in Syria, made no statement.
The Israeli military last admitted to air strikes in Syria last month, when it admitted it had struck Iranian military targets.
Syrian President Bashar al-Assad is a close ally of the regime in Tehran.
Israel considers Iran its biggest strategic threat and has said it will not permit an Iranian military presence on its borders.