Thirteenth seed Diego Schwartzman won an all-Argentinian affair 6-2, 7-6, 6-2 against Federico Debonis in the Men’s Singles.
Noah Rubin, the former Wimbledon junior champion, was eliminated in four sets by Mikhail Kukushkin Kazakhstan.
There was also a victory for Julia Glushko over Monique Niculescu of Romania in the Ladies Singles. The Israeli battled back from a set down to win 7-5, 6-4, despite injuring her knee in the second set when she crashed into the post of the net and needed medical attention for 10 minutes.
Glushko said: "I felt fantastic after the match and really good about the victory. It was a long and tiring game but I've seen the doctor and my knee is fine and he has confirmed that I'll be fit for my next match. I need to rest up to be strong for that."
Having come through three qualifying rounds, to reach the main draw of her first grand slam tournament since 2014, Glushko can expect to rise to about 128 in the world rankings. Glushko, 28, was outside the world's top 300 in April but has had a remarkable run of form since hiring Amir Hadad and Keren Shlomo as her personal coaches.
She is due to play world number 20 Naomi Osaka from Japan on Thursday