Jesse Levine moved into the second round of the Men's Singles after opponent Guido Pella was forced to retire in a five-set thriller on Court Seven on Tuesday.
Levine of America stormed into a two-set lead with some booming shots putting him in a strong position.
But Pella of Argentina fought back to win the next two sets, only for a leg injury to end his chances.
Levine won 6-4, 6-2, 4-6, 3-6, 4-3 (retired) and will line up against eighth seed Juan Martin Del Potro in the second round.
Wayne Odesnik went down in five sets in the battle of the qualifiers, losing to Jimmy Wan.
Tenth seeds Scott Lipsky and Santiago Gonzalez reached the second round of the Men's Doubles following a straight sets win over Paolo Lorenzi and Benoit Paire.
There was more disappointment for Israel, this time in the Men's Doubles, where Andy Ram and Eric Butorac bowed out in the first round, going down against Alexander Peya and Bruno Soares.
Full update in Friday's JC.