Wycombe raced into a 2-0 lead at White Hart Lane following two goals from striker Paul Hayes, with left-back Jacobson setting up the first with a pinpoint corner.
Son Heung-min and Vincent Janssen hauled Spurs level before substitute Garry Thompson headed in Myles Weston's cross with seven minutes to go to put Gareth Ainsworth's side back in front.
But super-sub Dele Ali levelled in the 89th minute before Son Heung-min completed a thrilling comeback in stoppage time.
Jacobson said: “It was a great occasion and we deserved a replay at the least. It was an amazing experience and game to be part of.