Israel will be looking to record a major surprise against a Spain team who lead Group G on goal difference from Italy, level on 10 points.
The visitors, a further point behind, began the campaign with a promising performance but a 3-1 home defeat against Italy but then beat Liechtenstein, Macedonia and Albania.
Israel boss Elisha Levy is able to name a full-strength squad with the exception of goalkeeper Dudu Goresh, who is suspended. Brighton's Beram Kayal returns while Levy has resisted recalling veteran players Yossi Benayoun and Tal Ben Haim on the grounds that he is building a team for the Euro 2020 qualifiers.
"They may be one of the best teams in the world, but we're not going to Spain to mess around," he insists.
"There's a buzz about our team after the last three wins."
SQUAD:
GOALKEEPERS
Ariel Harush (Hapoel Tel Aviv)
Ofir Marciano (Hibernian)
Boris Klaiman (Beitar Jerusalem).
DEFENDERS
Shir Tzedek (Hapoel Beer Sheva)
Eitan Tibi (Maccabi Tel Aviv)
Rami Gershon (Gent)
Taleb Tawatha (Frankfurt)
Eli Dasa (Maccabi Tel Aviv)
Dor Elo (Maccabi Petah Tikva)
Sheran Yeini (Maccabi Tel Aviv)
MIDFIELDERS
David Keltjens (Beitar Jerusalem)
Almog Cohen (Ingolstadt)
Bibras Nathko (CSKA Moscow)
Nir Bitton (Celtic)
Beram Kayal (Brighton)
Dan Einbinder (Beitar Jerusalem)
Lior Refaelov (Club Brugges)
Dor Micha (Maccabi Tel Aviv).
STRIKERS
Tomer Hemed (Brighton)
Tal Ben Chaim (Maccabi Tel Aviv)
Eran Zahavi (capt - Guangzhou)
Ben Sahar (Hapoel Beer Sheva)
Itay Shechter (Beitar Jerusalem)