The UK-based Syrian Observatory for Human Rights reported five killed, including one Syrian soldier, adding that a rocket warehouse was destroyed.
Israeli sources, which do not routinely acknowledge operations within Syria, made no comment on the latest strike.
However, it did acknowledge it had carried out earlier strikes in the province of Quneitra, saying it was in response to an unusual case of rocket fire from Syria late on Saturday.
The Syrian Observatory for Human Rights said 10 were killed in that strike, including Syrian soldiers and foreign fighters in the attack south of the capital.