Two of the casualties are believed to be seriously wounded, including a 22-year-old man, currently in surgery.
The third casualty, 21, was moderately wounded and the fourth is thought to have minor injuries.
MDA spokesperson, Zaki Heller, said: "Medics and paramedics assisted IDF paramedics on scene in treating the three wounded, including two in critical condition,"
The victims were taken to Beilinson Hospital in Petah Tikva.
Following the car ramming an Israeli was lightly wounded in a stabbing attack at the West Bank settlement of Beitar Illit,
A female attacker was shot at the scene.