City mayor Nir Barkat, a keen runner, also took part.
The race is regarded as particularly challenging because of the hilly course.
Israeli runner Guy Gordon told the Times of Israel: “It’s by far the hardest in Israel and one of the hardest in the world.”
“In marathon tourism, there’s the bucket list of the classic five and a few wild cards, and Jerusalem has become one of the wild cards,” he added.
Thirty-seven runners were injured during the race, with one being evacuated to Shaare Zedek Hospital suffering heat stroke.
