The future of the Iran nuclear deal has been in the balance since US President Donald Trump announced the US would withdraw from the agreement.
Britain, France and Germany said they remained committed to the deal, which was agreed by Mr Trump's predecessor Barack Obama.
Speaking in the Knesset on Monday night, Mr Netanyahu said: “There were years when we stood alone against these two threats [of Syria and Iran], but I think the situation has changed for the better.
“Of course I’ll present the things that are essential for Israel’s security.
“Regarding Syria, our position is clear: We believe there’s no room for any Iranian military presence in any part of Syria.
“And this obviously isn’t our position alone; I can say with confidence that it also represents the positions of others in the Middle East and also outside it.”