It organised the massive demonstrations in the plaza outside the Tel Aviv Museum of Art, later renamed Hostages’ Square, and was prominent in protests calling for an end to the war.
Now, though, with just three deceased hostages remaining in Gaza, all due to be returned in the near future, the group is paring back its day-to-day activities.
The organisation announced it would close down its headquarters in Tel Aviv and offer its remaining financial resources to the three final families.
A number of volunteers will also stay on to support the families through their loved ones' eventual returns.
Lior Chorev, the Forum's head of strategy, said: "The official struggle is over.
"There’s a hostage deal, and the US and Israel stand behind it.
"We have to adapt our activities to the fact that there is a deal, and a process that isn’t up to us.
"It doesn’t seem right to continue the rallies because it doesn’t serve [the remaining hostages]."
The move will not affect the similarly named Hostages and Missing Families Forum UK, based in Britain, which is separate from the Israeli version.
The three remaining hostages have been named as Dror Or, Ran Gvili, and Sudthisak Rinthalak.
Ran’s sisters, Shira Gvili, told Channel 12: “[The Forum] created this loving embrace for us.
"You can’t have an entire building for three families. The struggle is more intimate now.”