But Israel fears the deal would leave the Iranian regime with more freedom to pursue military activities in the Middle East.
In a press conference on Sunday, Mr Blinken said Israel and the USA saw “eye to eye” on the need to prevent an Iranian nuclear bomb.
But he stated that the Joint Comprehensive Plan of Action was the best way forward. The original JCPOA to curb Iranian nuclear ambitions was agreed in 2015 but President Trump pulled out of it three years later.
According to the Times of Israel, Mr Blinken said, “The US will continue to stand up to Iran when it threatens us or when it threatens our allies and partners.”
The Secretary of State is due to meet Israeli Prime Minister Naftali Bennett and see Palestinian leader Mahmoud Abbas during a five day visit to the Middle East.