Israeli Prime Minister Benjamin Netanyahu sent a letter to US President Barack Obama on Tuesday morning.
Mr Netanyahu wrote: “On behalf of the government and people of Israel, I offer our heartfelt condolences to you and to the people of the United States on the massive tornado that struck in Oklahoma and exacted such a horrific toll in human life.”
“Our thoughts and prayers are with the victims of this tragedy and their families at this difficult time.”
The Union for Reform Judaism has also started to collect funds which will be donated to relief groups on the ground.
President of the union Rabbi Rick Jacobs said: “We are numb with grief, and yet inspired by the heroic resilience of the people of Oklahoma.”
“Our thoughts and prayers go out to all those impacted by this horrific tragedy."
The Jewish Federations of North America and B'nai B'rith International have also started funds to aid the relief effort.