She was recognised as a righteous among the nations in 1965 and received a number of honours, including Poland’s Order of the White Eagle.
Polish ambassador Arkady Rzegock, who joined communities minister Robert Jenrick at the unveiling ceremony in Newark on Saturday, praised the “fitting tribute to a WW2 hero”.
The statue - mostly funded by the Institute of Polish Remembrance - was created over a six month period.
Artist Andrew Lilly said the work’s prominent location will help reach many people in the area.
“Knowing that the story of this little lady who stood up to the cruelty of the Nazi war machine will be on show for everyone to see, especially younger audiences, is really rewarding.
“Her actions during World War II should be remembered for generations and it’s great I can do my part to share her story,” she said.
The local council leader David Lloyd said Ms Sendler’s sacrifice “will be remembered for generations to come” and noted Newark’s “deep rooted connection” to the Polish community.
Olivia Marks-Woldman, chief Executive of the Holocaust Memorial Day Trust, said she “saved an amazing number of young lives while still being a young woman herself."