In a post on Twitter, the Board said: "The Guardian's decision to publish an opinion piece titled 'Israel must stop weaponising the Holocaust' was unbelievably crass.
"The article's failure, for example, to acknowledge the decades-long comparison of Israel to the Nazis - including in Hamas's genocidal founding charter - sums up the astonishing lack of judgement exhibited. Its publication marks a new low for the paper."
Former Guardian writer Hadley Freeman also accused the paper of "moral bankruptcy" saying: "I try to avoid criticising my former employer. I also support the freedom of opinion writers to write whatever they believe. But it is also my right to say: wow, this is intellectually, historically and morally bankrupt."
Segal, who is employed by Stockton College in New Jersey, also asserted in a piece for left-wing outlet Jewish Currents that Israel was using the Holocaust to boost its weapons industry.
In a statement, the Guardian said: "Our opinion columns often provoke robust discussions given the varied viewpoints of writers and readers and we value all feedback. The Guardian has consistently described the events of October 7 as an unjustified attack on Israeli civilians, as did this column, written by Raz Segal, an Israeli associate professor of Holocaust and genocide studies. We encourage our readers to review this column in full - excerpt provided below.
"This historical context in no way justifies or excuses the mass murder of 1,500 Israelis on 7 October, which constitutes a war crime and crimes against humanity. This was the single largest massacre of Jews since the Holocaust, which deeply shocked Jews and many others around the world. The context of the Hamas attack on Israelis, however, is completely different from the context of the attack on Jews during the Holocaust."