Emergency service crews wearing high-vis jackets were seen gathering around a nearby fruit and veg store treating a victim.
The London Ambulance Service sent six ambulance crews to the scene just after 9.30am on Friday morning.
A Hatzola ambulance crew took one person to hospital – while another four were taken to a major trauma centre following the incident.
Road closures remained in place with Clapton Common and Cazenove Road shut in both directions.
Police remained at the scene of the collision which took place on Friday morning.
The London Ambulance Service (LAS) confirmed four people had been taken to a major trauma centre following the incident.
A police spokesman said: "Police and London Ambulance Service are in attendance at a collision in Stamford Hill, N16.”
Local Shomrim tweeeted saying they wished to reassure the community the “incident is not terror related but rather a horrendous accident road closures remain in place we wish all the best to the injured.”
An investigation is ongoing and there have been no arrests - anyone with information should call 101 with reference CAD/1782.
