Mr Cameron is also expected to tour the Yad Vashem Holocaust museum. A delegation of business leaders is thought to be travelling with him, and will highlight the work done by the UK-Israel Tech Hub set up by British Ambassador Matthew Gould.
A joint press conference with Mr Netanyahu is also likely.
It is thought Mr Cameron will also travel to Ramallah to meet Palestinian leaders and back the establishment of a Palestinian state.
Downing Street does not comment on Mr Cameron's travel plans and has not confirmed details of the long-awaited visit.
Israeli Ambassador to Britain Daniel Taub said last week that he had informed Downing Street of the labour dispute and warned of the possible need to cancel the trip.
The Israeli Foreign Ministry is understood to have called off plans for a delegation from the Vatican to visit Jerusalem next week. The Pope plans to visit the Holy Land in May, but his trip may be scuppered by the strike action.
When Mr Netanyahu visited Los Angeles last week no diplomats from the consulate in the city were present to greet him. His entourage was left stranded by the runway due to a lack of official transport.
