Italy forged ahead on 18 through Riccardo Saponara and Italy stepped up a gear after the 37th minute dismissal of Golasa, with Manolo Gabbiadini (2) and Alessandro Florenzi finding the net.
Luzon said: "Israel can't play against Italy with ten players. I have no complaints with my players – each and every one of them gave 100% on the pitch."
Israel's Eliazer Dasa commented: "It's a very good experience to play against such great players."
Israel now has a mountain to climb. They must beat England on Tuesday to stand a chance of progressing, while Italy know they will top the section should they avoid defeat by Norway.