Dudi Sela was eliminated in the first round of the US Open after bowing out in four sets against Pablo Cuevas.
After losing the opening set 6-2, the Israeli bounced back to level the match and take the second 6-3.
But the Uruguayan stepped up a gear to progress into round two, winning the next two sets 6-4, 6-1.
There was better news for Diego Schwartzman who overcame Elias Ymer of Sweden in straight sets.