Mid-table Heaton Park grabbed a late consolation via Daniel Franks, but Manchester Maccabi 3rds were always cruising thanks to their early four-goal blitz.
"It was a case of job done in the first-half as we went four goals up," said Richard Hamburger.
"We made a few changes and the intensity dropped off a little.
"But we were always in control thanks to our start. Credit must go to Heaton Park who never gave up."
Heaton Park boss David Seligman admitted defensive errors proved their downfall.
"We were organised against a very good side, but unfortunately individual errors cost us," he said.
"That can have a demoralising effect. But I felt the scoreline did not do us justice."
Report written by Darren Witcoop