Hapoel beat Inter Milan twice and drew twice with Southampton, beating them on away goals, in the Europa League Group Stage, to qualify for the knockout round.
However, Hapoel lost twice to Slavia Prague, leaving them in second place in Group G and in the unseeded half of the draw today.
Hapoel manager Barak Bakhar said: "It's an interesting draw against a very tough team.
"It will be a challenge but we will find out about them and come prepared for the matches in the best possible way.