The hosts improved as an attacking force towards the latter stages, with former Chelsea striker Ben Sahar and Maor Buzalgo coming on, but it was a comfortable night for Fraser Forster who was rarely tested in a lacklustre contest.
The draw means Southampton stay top of Group K on goal difference from Hapoel.
Southampton boss Claud Pael said: "It was a good result against a very good team. When you cannot take three points it's important to take one and it's an important one for the future.
"Maccabi are a physical, tactical and technical team who gave us a difficult game."
Sparta Prague are the next visitors to the Turner Stadium on October 20.
Maccabi Tel Aviv suffered an embarrassing 1-0 defeat against part-timers Dundalk who became the first Irish team to win a match in the European group stages.