In October 2018 the shooter entered the Tree of Life Congregation synagogue in the city's Squirrel Hill neighbourhood, during a baby-naming service.
Prosecutors said they believe the death penalty is justified because Mr Bowers’s antisemitic views played a role in the shooting.
According to a federal notice prosecutors will argue that the shooting was intentional and he showed no remorse.
Mr Bowers faces 63 federal charges, including use of a firearm to commit murder, and hate crime charges.
A Justice Department news release in January said of the 63 charges that he faces, 22 carry the death penalty.