Jonathan Sacks is due to receive the Bradley Prize for outstanding achievement at a ceremony in the US next month.
Lord Sacks will receive $250,000 (£173,375.73) as part of the award from The Lynde and Harry Bradley Foundation, for his “exceptional contributions to affirming life's spiritual dimension”.
President and CEO of the Bradley Foundation, Michael Grebe, said: “Rabbi Lord Jonathan Sacks has distinguished himself as a leading moral voice in today’s world.
“He is a world leader in the defense of religious liberty, decrying violence perpetrated in the name of religion and exploring the compatibility of religion and science.”