Jonathan Sacks is due to receive the Bradley Prize for outstanding achievement at a ceremony in the US next month.
Lord Sacks will receive $250,000 (£173,375.73) as part of the award from The Lynde and Harry Bradley Foundation, for his “exceptional contributions to affirming life's spiritual dimension”.
President and CEO of the Bradley Foundation, Michael Grebe, said: “Rabbi Lord Jonathan Sacks has distinguished himself as a leading moral voice in today’s world.
“He is a world leader in the defense of religious liberty, decrying violence perpetrated in the name of religion and exploring the compatibility of religion and science.”
The Bradley Foundation, which supports scholarly studies and academic achievement, will hand out four prizes this year. Lord Sacks will be presented with the award at a ceremony in the John F. Kennedy Centre for Performing Arts in Washington, D.C.
The selection was based on nominations submitted by more than 200 prominent individuals across the country and chosen by the Bradley Prizes Selection Committee.
Earlier this year, the Emeritus Chief Rabbi won the internationally-renowned Templeton Prize which carries a cash prize of £1.1million.