Hendon, who won the title by eight points last season, will look to open their account against a young HMH team managed by Avi Goldberg.
Elsewhere in the Premier Division, newly-promoted Faithfold Doc MM A face a tough looking test against Maccabi London Lions at Rowley Lane.
Division Two champions Fairlop FC start life in the first division with a home match against the returning Jewdinese.
The stand-out game in Division Two sees Mitch Young's FC Team host fellow title hopefuls Mill Hill Dons.
Hendon are also in action this weekend when they take on League Cup winners Oakwood A in the Charity Shield.
WEEK ONE FIXTURES
Hendon United Sports vs HMH
Maccabi London Lions vs Faithfold Doc MM A
Bayern Mincha vs Los Camden A
Fairlop FC vs Jewdinese
North London Raiders A vs Redbridge Jewish Care A
Faithfold Doc MM B vs SPEC FC
FC Team vs Mill Hill Dons
Hertswood Vale vs Temple Fortune
Scrabble FC B vs North London Raiders Masters