Ryan Kramer, Harry Moss, Adam Morrow, super-sub Richard Reback and Sam Demby did the damage in MHD's ninth win in 10 matches.
The Dons started the game slowly - they strugged to get things going and passing were going astray. That was until the 30th minute when a mix-up between the Fortune keeper and defence, left Kramer an open goal to slot in from close-range.
It was 2-0 10 minutes later, Kramer involved again, this time he delivered a perfect inswinging corner which was met by the head of Reback, whose goal was his first ever in a Dons shirt.
Shortly after Morrow also got his first Dons goal when a ball by Kramer was flicked on by Moss to find Morrow in the box who finished superbly.
A shove in the back on Morrow in the penalty box 10 minutes into the second half, led to Moss stepping up to calmly place the resulting penalty in the bottom left-hand corner
Demby added the gloss with goal No. 7 in the closing moments of the game following a great through ball from Joel Sinclair-Horne. Demby ran from the halfway line down the wing to then calmly slot it past the goalkeeper.
Delighted Dons boss Brandon Hamme told JC Sport: "The boys got stuck in and gave it 110 per cent throughout.
"The pitch conditions weren't ideal but we still managed to get the ball down and play some great football.
"The Fortune boys showed they were no pushovers as they did have a considerable amount of possession but yet another great defensive performance kept them at bay throughout."
The Dons have won nine out of their opening 10 matches and Hamme continued: "We are at the halfway stage now and we will being doing our upmost to try to replicate our impressive first half of the season when we start the second half next week against an inform Real Hendon team."
Fortune joint-manager Darren Zitren told JC Sport: "It was a frustrating game where I would say Fortune appeared on top for most of the first half (and a large part of the second).
"A defensive error left us undeservedly 1-0 down and heads dropped. We started the second half strong again and had several chances to get back into the game, hitting the crossbar and several efforts going narrowly wide.
"The scoreline doesn’t reflect the game and the fantastic effort from our lads today. Full credit to MH Dons as they took their chances."
DONS: Oliver Burchell, Josh Cinna, Sam Denby, Adam Diamond, Ryan Kramer, Adam Lisberg, Adam Morrow, Jamie Nagioff, Joel Sinclair-Horne, Jason Weldon, Harry Moss. Subs: Josh Moses, Richard Reback, Jordan Rinsler
SCORERS: Kramer, Moss, Morrow, Reback, Demby
FORTUNE: Anthony Beilin, Gideon Caplin, Simon Cohen, Joshua Klepper, Ben Lewis, Eric Lewis, Zachary Rich, Gabriel Saul, Oliver Segal, Gideon Wetrin, Jonathan Winton. Subs: Jeff Bathija, Jonathan Black, Adam Jacobs, Darren Zitren