Ilford Federation Synagogue has put its Coventry Road building up for sale and has its eye on a new home a mile away.
The 450-family congregation hopes to move north to the Jewish Care-owned Dennis Centre in Beehive Lane.
But the plan will depend on Redbridge Council granting planning permission to convert the centre into a synagogue.
Shul chair Leon Newmark said the proposed relocation would make it more accessible to members.
“It would be a more modern building in the area we are looking for.”
“A number of buyers” were interested in the Coventry Road site.
The Dennis Centre was originally the home of Ilford United Synagogue, which is now located elsewhere in Beehive Lane.
Although a merger between the Federation and United communities has been discussed in recent years, Mr Newmark insisted that it “will not happen”.
The council is due to discuss the synagogue’s planning application next month.