Two goals from James Ryan helped FC Team A cause shock of the round as they beat Premier Division Hendon United B in the Peter Morrison Trophy. Gav Noe had hauled Hendon level but Ryan's late winner set up a tie against Leeds Maccabi.
North West Neasden A set up a last 16 clash at South Manchester Maccabi 1st after thumping minnows Blizzard Storm 9-0. Tony Keterman (4), Lee Cash, Ben Ellis, Darren Yarlett, Matt Sofier and Scott Shindler eased them through.
Rob Lerner was among the goals as Brady Maccabi came from behind to beat Division One rivals Southgate Harmen A 2-1. Jonathan Hirshler netted for Harmen.
Danny Hakimi and Lewis Walker guided Redbridge Jewish Care A past Temple Fortune.
A missed penalty from Saul Conway prevented Hendon A from closing the gap on JC MSFL Premier Division leaders London Maccabi Lions A. Ari Last struck for Hendon while Joel Ross was the scorer for the Lions.
Craig Edwards, the new manager of South Manx, made a winning start after they beat Lions B 3-2 with goals from Jonny Haik (2) and Kane Swerner. David Dinkin and Jon Green netted for Lions.
North London Raiders A moved five points clear in Division One after beating Camden Park thanks to a header from top-scorer Jonny Blain.
Simon Peterman was the matchwinner as Montana A condemned Neasden B to their first defeat of the campaign.
James Taylor (2), Richard Caplin and Rob Gevertz were on the mark as Redbridge B took maximum points from a double-header against Brixton.
Gary Bloch (2), Ian Tussie, Dan Ash, Dan Geey and Ben Myers helped Oakwood keep alive promotion hopes with two wins over Red Sea.
Chigwell Athletic came from 3-1 to draw against Division Two leaders North London Raiders B. Steve Bloom (2) and Jonny Hesselberg put Raiders in the box seat but the East Londoners hit back through Russell Becker, Russell Lawson and Doron Weinstein.
Alex Cooper bagged a brace as Lions C drew 2-2 against Harmen B. Dan Henig and Alex Hershman replied.
Richard Salmon, Dom Berko and Adam Rones earned FC Team B a 3-1 win over Faithfold B.
David Natas earned Holy Mount Zion a draw against Rapid Banta for whom Adam Kaldor found the net.
Andy Levy took Woodford Wanderers three points clear at the top of Division Three as they overcame Faithfold C.
A hat-trick from Joel Isaacs lifted Catford & Bromley off the foot of the table with a 3-2 win over Hendon C. Trevor Silverman and Zvi Noe replied.
Matt West and Jonathan Marrache were on the mark as FC Marylebone overcame L'Equipe.
Josh Toff (3), Dan Ezra (2) and Byron Watkins steered Zig Zag to a 6-3 win over FC Heath.
Justin Freedman, Steve Howard and Rob Silverman were among the goals as Team JLGB beat Division Four leaders Glenthorne United 5-3. David Blackman and Jamie Crawford replied.
Adam Seres and Rob Burstein maintained UJS Norstar Bs' title hopes in a 2-1 win over UJIA.
Gabriel John (2), Louis Taylor (2), Gabriel Saul and Warren Schenk were on target as Jewventus grabbed a pair of wins over Athletic Bilbaum.
A four-goal blast from Adam Jason inspired Pinner JFC to a 5-2 win over Highgate & Muswell Hill. Dean Shaw scored the other. Danny Feuer and Andrew Greenwall-Cohen accounted for the HMH goals.